Cross Ethnics Genome Wide Meta-Analysis
About Course
Course Overview
Conduct cross-ethnic genome-wide meta-analysis and gene-based rare variant association studies. Master FGWAS methodology, Bayesian approaches, and multi-population analysis techniques.
What You Will Learn
- Meta-analysis methods (fixed-effect, random-effect, MANTRA)
- Cross-ethnic GWAS design and challenges
- Gene-based association tests (SKAT, SKAT-O, burden tests)
- Rare variant analysis strategies
- Trans-ethnic fine mapping
- Functional annotation and variant prioritization
Prerequisites
Strong statistics background. Completion of GWAS fundamentals course recommended.
Duration
6 weeks, 3-4 hours per week
Level
Advanced