Polygenic Risk Score And GWAS
About Course
Course Overview
Learn to conduct genome-wide association studies for case/control and quantitative traits. Master advanced result presentation, interpretation, and individual disease risk prediction using Polygenic Risk Score techniques.
What You Will Learn
- GWAS study design and quality control (PLINK)
- Association testing for binary and quantitative traits
- Manhattan and QQ plot generation and interpretation
- Multiple testing correction and significance thresholds
- PRS construction methods (C+T, LDpred2, PRS-CS)
- PRS validation, calibration, and clinical interpretation
Prerequisites
Statistics and genetics fundamentals. R programming experience required.
Duration
8 weeks, 4 hours per week
Level
Advanced