Fine Mapping Genotypes Imputation Data

Course Overview

Master statistical fine mapping techniques and genotype imputation methods. Learn to identify causal variants, perform credible set analysis, and impute missing genotypes using international reference panels.

What You Will Learn

• Genotype imputation with IMPUTE2 and Minimac4
• Reference panels (1000 Genomes, HRC, TOPMed)
• Imputation quality metrics and filtering
• Statistical fine mapping (FINEMAP, SuSiE, CAVIAR)
• Credible set construction and interpretation
• Colocalization analysis (coloc, eCAVIAR)

Prerequisites

Strong statistical genetics background. Experience with GWAS analysis.

Duration

6 weeks, 3-4 hours per week

Level

Advanced